Comparative Study of Centrally Acting Skeletal Muscle Relaxant Activity of Aqueous Extract of Cinnamomum zeylanicum Bark with Methocarbamol on Albino Mice
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چکیده
Cinnamon bark is used as a spice. It is employed in cookery as a condiment and flavouring material. The essential oil of this herb is a potent antibacterial, anti-fungal, and uterine stimulant. It is useful in diarrhoea and haemorrhage of the womb. It also reduces blood sugar and cholesterol level. One of its uses is in musculoskeletal disorder. The aim of the study was to evaluate the centrally acting skeletal muscle relaxant activity of aqueous extract of Cinnamomum zeylanicum bark in albino mice using methocarbamol as a standard drug. The mice were divided into three groups to receive the following treatments: group 1, control (distilled water); group 2, standard drug (methocarbamol 60mg/kg suspended in distilled water); group 3, test drug (aqueous extract of Cinnamomum zeylanicum bark (ABCZB) 200mgkg suspended in distilled water). Various preliminary phytochemical group tests of the aqueous extracts of Cinnamomum zeylanicum bark was performed by the standard methods. Aqueous extract of Cinnamomum zeylanicum bark (AECZB) showed better muscle relaxant effect as compared to standard drug (Methocarbamol, 60 mg/kg). As this aqueous extract is having antioxidant properties, so it shows fewer side effects as compared to methocarbamol. The result from the Rotarod test showed that the extract significantly reduced the motor coordination of the tested animals. These results demonstrate that the aqueous extract of Cinnamomum zeylanicum bark possesses better skeletal muscle relaxant activities than that of the standard drug used.
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